Cervical cancer is the third most common type of malignant tumor and the fourth leading cause of cancer-associated mortality among women worldwide 1. It is well known that human papilloma virus HPV infection is essential in cervical carcinogenesis 3 , but HPV infection alone is not sufficient to transform epithelial host cells into cancer cells. Therefore, other factors, including the upregulation of oncogenes and aberrant activation of associated signaling pathways, may be involved in cervical carcinogenesis. Pomegranate Punica granatum , an ancient fruit known to offer beneficial effects in medicine, is now being recognized as a potential chemopreventive and anticancer agent. Increasing evidence has confirmed the cancer preventive efficacy of pomegranate in vitro and in in vivo animal models, including breast, skin, prostate, lung and colon cancers 5 — Previous investigations have revealed that PUN has effects on various tumor cell lines, including upregulating the expression levels of B-cell lymphoma-2 Bcl-2 -associated X protein Bax 7 , 10 , Bclassociated death promoter 10 , cleaved poly ADP-ribose polymerase PARP 7 , 18 , 19 and cytochrome c 8 ; promoting the activation of caspase-3 8 and caspase-9 18 ; and downregulating the expression of Bcl-2 7 , 18 , Bcl-extra large XL 7 , 8 , 10 and cell cycle proteins, including cyclin A 8 , 18 , cyclin B1 8 , 18 , cyclin D1, cyclin D2 and cyclin E 7 , in addition to regulating the proliferation and apoptosis of cancer cells.
Prevent Breast Cancer With Pomegranates
The Powerful Health Benefits Of Pomegranates - ttag.info
Studies have shown that the extracts of the parts of the fruit also possess anticancer activity. The mechanisms of action are diverse and include interference with tumor cell proliferation, cell cycle, invasion, and inhibition of angiogenesis. Pomegranate is a fruit abundant in polyphenols, hydrolysable tannins punicalagin, pedinculgin, punicallin gallic and ellagic acids, esters of glucose anthocyanins and other polyphenols, and anthocynidins such as delphinidin, cyanidin, and pelargonidin. The concentration of polyphenols in pomegranate 3. Therapeutically significant constituents of pomegranate include ellagic acid, ellagitannins including punicalagins , punicic acid, flavanoids, anthocyanidins, anthocyanins, and estrogenic flavonols and flavones.
The Powerful Health Benefits Of Pomegranates
The key seems to be a phytochemical, ellagic acid, found in pomegranates. It inhibits aromatase, an enzyme linked to the development of estrogen-responsive breast cancer. But, phytochemicals in pomegranates and in grapes are different. More studies are needed, Gary Stoner, a professor in the department of internal medicine at Ohio State University, said in the same news release.